Comparison of letrozole and clomiphene citrate efficacy in terms of ovulation induction and pregnancy rate.

Objective: To compare the efficacy of Letrozole and clomiphene citrate in Patients Anovulation polycystic ovarian syndrome with Infertility. Study Design: Randomized Controlled Trial Setting: Department Obstetrics Gynecology Independent Medical College Faisalabad. Period: 30-09-2019 to 29-6-2020. Material & Methods: This study included 100 patients 50 each group. Group A received 2.5 5mg letrozole cycle from day 3 7. B mg incremental dose depending on response. Both Drugs were given for consecutive 6 cycles see Main outcome Measure optimal follicle size (> 18mm), endometrial thickness, pregnancy rate. Epidemiological data measures recorded a Performa. Statistical analysis was done using SPSS version 13. Chi-square test applied p-value <o.o5 considered significant. group primary infertility patients. Results: The mean age 28.03+ 3.02 years. Mean 29.04+3.44 28.47+3.90 Mono ovulation (88.9%) 27 b (60.0%). thickness 9.6mm + 1.6 6.9mm 1.2 A. In 18% got pregnant 1.1% B. Conclusion: Efficacy significantly higher as compared echo citrate. effects showed better terms Ovulation Induction Endometrial Thickness Pregnancy